Watch Intently (one)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Mitotane is a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for possible dosage adjustments.Use of benzodiazepines, which include diazepam, both of those made use of on y